Modeling anti-CD19 CAR T cell therapy in humanized mice with human immunity and autologous leukemiaResearch in context

Background: Adoptive immunotherapy using T cells expressing chimeric antigen receptors (CARs) targeting CD19 has produced remarkable clinical outcomes.However, much of the mechanisms of action, such as the development of memory responses and sources of immune cytokines, remain elusive largely due to the challenge of characterizing human CAR T cell

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